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FFA2 is activated predominantly by propionate and FFA3 by butyrate [EC 50 for acetate, propionate and butyrate at FFA2 are 431, 290 and 371 μM respectively, and at FFA3 393, 41 and 33 μM (Brown et al., 2003)]
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Factors like starting dose, dosing schedule, meal size, and genetic susceptibility to GLP-1 sensitivity all influence how long nausea persists